Substrate: Mitogen-activated protein kinase kinase kinase 1 (Ser/Thr protein kinase family. MAP kinase family)
Seq-ID: P53349 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-5209635   GRAP1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
ATP binding,
JUN kinase kinase activity,
zinc ion binding		 camera-type eye development,
regulation of cell migration,
activation of JUN kinase activity,
apoptotic mitochondrial changes,
positive regulation of actin filament polymerization,
transforming growth factor beta receptor signaling pathway,
wound healing
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 142 LAAARDSGARSPAGAEPPSAA - 19144319
HTP
0.12
 - -
0.89
 - medium
T 1381 GAAARLASKGTGAGEFQGQLL MAP3K1 9065412
LTP
1.00
 - S_TKc
0.26
 - medium
T 1381 GAAARLASKGTGAGEFQGQLL MAP3K1 9078260
LTP
1.00
 - S_TKc
0.26
 - medium
T 1393 AGEFQGQLLGTIAFMAPEVLR MAP3K1 9065412
LTP
1.00
 - S_TKc
0.14
 - medium

Substrate: Mitogen-activated protein kinase kinase kinase 1 (Ser/Thr protein kinase family. MAP kinase family)
Seq-ID: Q13233 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48271   BAG2_HUMAN
MINT-48272   AIFM1_HUMAN
MINT-48274   HS71L_HUMAN
MINT-48275   TCPQ_HUMAN
MINT-48276   GRP78_HUMAN
MINT-48277   HSP7C_HUMAN
MINT-48278   RL4_HUMAN
MINT-48281   ADT2_HUMAN
MINT-48283   GRP75_HUMAN
MINT-48284   SYMC_HUMAN
MINT-48285   RLA2_HUMAN
MINT-48286   RUVB2_HUMAN
MINT-48288   EPIPL_HUMAN
MINT-48291   DNJA1_HUMAN
MINT-48292   CDC37_HUMAN
MINT-48294   EF1A2_HUMAN
MINT-48296   TCPA_HUMAN
MINT-48298   AAAT_HUMAN
MINT-48299   MYH10_HUMAN
MINT-48300   PYR1_HUMAN
MINT-48301   IRS4_HUMAN
MINT-48302   ACTG_HUMAN
MINT-48303   RS6_HUMAN
MINT-48304   RL3_HUMAN
MINT-48310   RS14_HUMAN
MINT-48311   FAS_HUMAN
MINT-48314   GEMI4_HUMAN
MINT-48317   RL7_HUMAN
MINT-48319   ECHA_HUMAN
MINT-48321   TBB6_HUMAN
MINT-48322   RL14_HUMAN
MINT-48323   CALM_HUMAN
MINT-48324   HPBP1_HUMAN
MINT-48326   TBB5_HUMAN
MINT-48327   TBB4_HUMAN
MINT-48328   RS27_HUMAN
MINT-48330   DNJA3_HUMAN
MINT-48331   FLNA_HUMAN
MINT-48332   DHX9_HUMAN
MINT-48333   RL18_HUMAN
MINT-48335   VIME_HUMAN
MINT-48337   H4_HUMAN
MINT-48338   RS8_HUMAN
MINT-48339   NOP2_HUMAN
MINT-48340   ADT3_HUMAN
MINT-48342   HS90A_HUMAN
MINT-48343   NUCL_HUMAN
MINT-48346   FKBP5_HUMAN
MINT-48348   HS105_HUMAN
MINT-48350   RL30_HUMAN
MINT-48352   HNRPM_HUMAN
MINT-48354   RL10_HUMAN
MINT-48356   RL24_HUMAN
MINT-48358   HS90B_HUMAN
MINT-48359   USP9X_HUMAN
MINT-48361   RS13_HUMAN
MINT-48364   MYO1D_HUMAN
MINT-50709   ESR1_HUMAN
MINT-3374124   BRAF_HUMAN
MINT-3391558   MP2K7_HUMAN
MINT-3391583   MP2K1_HUMAN
MINT-7288718   FLNB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
ATP binding,
zinc ion binding		 cytosol I-kappaB kinase/NF-kappaB cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 292 GRITPPRRAPSPDGFSPYSPE - 18220336
HTP
1.00
 - -
0.77
 - medium
S 292 GRITPPRRAPSPDGFSPYSPE - 18669648
HTP
1.00
 - -
0.77
 - medium
S 297 PRRAPSPDGFSPYSPEETNRR - 18669648
HTP
1.00
 - -
0.79
 - medium
S 300 APSPDGFSPYSPEETNRRVNK - 18669648
HTP
1.00
 - -
0.73
 - medium
S 507 SHDFYSHELSSPVDSPSSLRA - 18669648
HTP
0.51
 - -
0.44
 - medium
S 511 YSHELSSPVDSPSSLRAAQQQ - 18669648
HTP
1.00
 - -
0.55
 - medium

Substrate: Mitogen-activated protein kinase kinase kinase 1 (Ser/Thr protein kinase family. MAP kinase family)
Seq-ID: Q62925 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-5209624   GRAP1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
JUN kinase kinase kinase activity,
sphingolipid binding,
identical protein binding,
mitogen-activated protein kinase kinase binding,
mitogen-activated protein kinase binding,
JUN kinase binding,
ATP binding,
zinc ion binding,
MAP/ERK kinase kinase activity,
ubiquitin-protein ligase activity		 membrane fraction,
cytoplasm,
membrane		 response to osmotic stress,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of viral transcription,
negative regulation of actin filament bundle assembly,
positive regulation of apoptosis,
protein oligomerization,
peptidyl-serine phosphorylation,
protein amino acid autophosphorylation,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
activation of JNKK activity,
protein polyubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 67 WRRQQLRKVRSVELDQLPEQP PAK1 12228228
LTP
0.95
 - -
0.78
 - low

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